ABCG5/G8 Deficiency in Mice Reduces Dietary Triacylglycerol and Cholesterol Transport into the Lymph

The adenosine triphosphate‐binding cassette (ABC) transporter G5/G8 is critical in protecting the body from accumulating dietary plant sterols. Expressed in the liver and small intestine, it transports plant sterols into the biliary and intestinal lumens, thus promoting their excretion. The extent to which G5/G8 regulates cholesterol absorption remains unclear. G5/G8 is also implicated in reducing the absorption of dietary triacylglycerols (TAG) by unknown mechanisms. We hypothesized that G5/G8 suppresses the production of chylomicrons, and its deficiency would enhance the absorption of both dietary TAG and cholesterol. The aim of this study was to investigate the effects of G5/G8 deficiency on lipid uptake and secretion into the lymph under steady‐state conditions. Surprisingly, compared with wild‐type mice (WT) (n = 9), G5/G8 KO (n = 13) lymph fistula mice given a continuous intraduodenal infusion of [3H]‐TAG and [14C]‐cholesterol showed a significant (P < 0.05) reduction in lymphatic transport of both [³H]‐TAG and [¹⁴C]‐cholesterol, concomitant with a significant (P < 0.05) increase of [³H]‐TAG and [¹⁴C]‐cholesterol accumulated in the intestinal lumen. There was no difference in the total amount of radiolabeled lipids retained in the intestinal mucosa between the two groups. G5/G8 KO mice given a bolus of TAG showed reduced intestinal TAG secretion compared with WT, suggesting an independent role for G5/G8 in facilitating intestinal TAG transport. Our data demonstrate that G5/G8 deficiency reduces the uptake and secretion of both dietary TAG and cholesterol by the intestine, suggesting a novel role for the sterol transporter in the formation and secretion of chylomicrons.     

基于FPGA的多功能数字钟系统的设计与实现

【】它介绍了一种基于FPGA的多功能数字钟系统的设计方案,采用Verilog HDL编程语言以及Top-Down的模块化设计思想对整个模块作了详细的介绍。系统设计时为了满足不同人群的需要,增加一个模式选择按键,可以实现12小时、24小时两种计时方法的切换。整点报时功能采用蜂鸣器完成,当前时刻是几时蜂鸣器就响几下。通过Modelsim仿真,并且下载至FPGA开发板验证发现系统实现了预期的功能。     

基于调制边带法的高次倍频光毫米波产生

提出了利用外调制技术的调制边带法的六倍频和八倍频光毫米波产生方案。方案仅采用一个马赫曾德尔调制器,并利用其非线性传输特性,通过调节MZM 的偏置电压和调制电压,控制边带的强度,仅保留三阶边带或四阶边带,从而实现六倍频及八倍频光毫米波的产生。采用将基带数据信号仅调制在一个三阶边带或四阶边带分量的方式,有效防止走离。数值分析结果表明,提出的方案仅需10 GHz 及7.5 GHz 的调制信号频率就能得到60 GHz 毫米波,大大减小了调制信号频率,增加了上变频系数,传输距离可达160 km,而功率代价变化不大。与提出的其他高倍频技术相比,由于系统仅采用一个马赫曾德尔调制器,提出的方案系统结构更为简单,且此方案色散影响较小,传输距离更长。     

A Full Compositional Range for a (Ga1‐x Zn x )(N1‐x O x ) Nanostructure: High Efficiency for Overall Water Splitting and Optical Properties

Bulk (Ga_1‐x Zn _x )(N_1‐x O _x ) as a photocatalyst has received increasing attention as a potential solution for the energy shortage challenge; however, its catalytic performance is highly limited by its bulk form. To improve the photochemical potential, the nanoscale form of this multiple‐metal oxynitrides is desirable. In this work, a new type of (Ga_1‐x Zn _x )(N_1‐x O _x ) nanostructure is obtained. Its composition can tuned to the full range (0.18 < x < 0.95). The (Ga_1‐x Zn _x )(N_1‐x O _x ) nanostructure exhibits excellent photocatalytic activity for overall water splitting, and the highest quantum efficiency of (Ga_1‐x Zn _x )(N_1‐x O _x ) is as high as 17.3% under visible light irradiation. Using this new type of (Ga_1‐x Zn _x )(N_1‐x O _x ) nanostructure, the narrowing of the bandgap for (Ga_1‐x Zn _x )(N_1‐x O _x ) is not only due to an increase in the valence band maximum, but it is also related to a decrease in the conduction band minimum.     

一种低误报率的新型光纤分布式振动传感系统

针对目前-OTDR光纤分布式振动传感器由于散射光波光强不稳定造成误报率较高的问题,文中提出一种-OTDR和Mach-Zehnder干涉仪相结合的光纤分布式振动传感新系统,-OTDR和Mach-Zehnder干涉仪分别对外界振动进行探测,从而降低单一-OTDR探测的误报率。实验研究了-OTDR和提出的新的复合结构系统对外界振动探测的误报率,实验结果表明:在复杂环境下,与现有-OTDR方案相比,提出的基于-OTDR和M-Z干涉仪复合结构的方案可以有效降低系统的误报率,使系统的误报率由单一-OTDR的25%降至2%。     

温度控制与监测技术在大体积混凝土中的应用

近年来,社会经济和科学技术突飞猛进,超高层建筑越来越多.地下室底板大体积混凝土的厚度较大,且存在大体积承台,由于大量热量会伴随着混凝土水化过程而释放出来,从而引发混凝土内部温度升高,造成混凝土内外温差很大,容易导致混凝土出现温度裂缝.结合本公司在施项目工程实际,阐述了本项目温度监测及降温措施在大体积混凝土浇筑中的应用.     

纳米铜修饰多壁碳纳米管/石蜡相变驱动复合材料的制备及热性能

以油胺为分散稳定剂,在石蜡中热分解甲酸铜-碳纳米管复合物前驱体,单步制备了纳米铜修饰多壁碳纳米管(Cu-MWCNTs)/石蜡复合材料。通过XRD、TEM和DSC对Cu-MWCNTs/石蜡复合材料的物相、微观形貌及相变行为进行了表征和分析,并对其热敏性、热膨胀性和热稳定性及影响因素进行了分析研究。结果表明:纳米Cu原位沉积在MWCNTs外壁上,粒径为2~35nm。与纯石蜡相比,Cu-MWCNTs/石蜡复合材料的相变温度和相变潜热均明显降低。Cu-MWCNTs含量为0.2wt%的Cu-MWCNTs/石蜡复合材料具有较短的升温时间,体膨胀率降低较小,且多次加热后稳定性较好,可作为此类热敏微驱动器的理想材料。     

Analysis of the mechanism and failure mode of landslides subjected to transient seepage in a Piedmont region of Nanjing area

Bulletin of Engineering Geology and the Environment - The landslide mechanism and failure mode of the gently sloping Piedmont region are analyzed in Fangshan and Zhutoushan hills in the...     

An Integrated Flexible All-Nanowire Infrared Sensing System with Record Photosensitivity

Infrared (IR) photodetectors are a key optoelectronic device and have thus attracted considerable research attention in recent years. Photosensitivity is an increasingly important device performance parameter for nanoscale photodetectors and image sensors, as it determines the ultimate imaging quality and contrast. However, photosensitivities of state-of-the-art low-dimensional nanostructure-based IR detectors are considerably low, limiting their practical applications. Herein, a biomimetic IR detection amplification (IRDA) system that boosts photosensitivity by several orders of magnitude by introducting nanowire field effect transistors (FETs), resulting in a peak photosensitivity of 7.6 × 10⁴ under an illumination of 1342 nm, is presented. Consequently, high-contrast imaging of IR light is obtained on the flexible IRDA arrays. The image information can be then trained and recognized by an artificial neural network for higher image-recognition efficiency. This work provides a new perspective for developing high-performance IR imaging systems, and is expected to undoubtedly enlighten future work on artificial intelligence and biorobotic systems.